This world-class museum is not to be missed, but where to start, with more than 350 rooms? Skip the lines by buying tickets online, then hit the highlights. Room 214: a diminutive duo of sublime Madonna paintings by Da Vinci, in one of the palace's most ornate chambers. Room 246: 26 portraits by Van Dyck. Room 247: a gallery of robust, fleshy Rubenses. And Room 254: Rembrandt's Danae, miraculously restored after being defaced in 1985.

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